We report on our ongoing project ``Statistical studies of HII regions in the nearby extra-galaxies''. We present an overview of our detailed study of warm dust in the nearby Galaxy NGC 4321 (M100), measuring the flux values in the 4 Spitzer-IRAC bands of some 275 HII regions in M100. In addition, we present new measurements of the flux values in the 4 Spitzer-IRAC bands of a complete sample of 70 isolated luminous HII regions in NGC 4736 and 157 regions in NGC 4254. We study the relations between the Hα luminosity and the near-IR luminosity and temperature of HII regions in the three galaxies. We estimate the near-IR luminosities and compare them with the Hα luminosities from archive and literature sources. We find a linear relation between the Hα luminosity and the IRAC luminosity for the HII regions, but no apparent relation between the luminosity and the colour temperature of the regions in any of the three galaxies. The colour temperatures of regions especially in M100 and NGC4254 are confined to a surprisingly narrow range, with a small fraction forming a higher temperature tail to the distribution. These results give new insight into the size function and the 3D distribution of the dust in these regions, and we propose scenarios to explain them.