In recent years, major changes were done at the IRAM Plateau de Bure interferometer and 30-meter telescope, in particular in the areas of receivers and back-ends. These enhancements increased in significant ways both the sensitivity and the efficiency of both IRAM facilities. I will present results obtained on high-z (2 < 6.4) sub-millimeter galaxies and quasars that illustrate the progress that has been made, emphasizing recent follow-up observations of sources that were uncovered in the Herschel surveys. The talk will end with a presentation of the future projects that are currently under discussion at IRAM, including the NOrthern Extended Millimeter Array (NOEMA), as well as the prospects offered by ALMA.